Allo-SCT treatment of diffuse

The journal of Clinical Oncology (J Clin Oncol) according to a study published online in the near future, autologous hematopoietic stem cell transplantation (ASCT) recurrence of diffuse large b-cell non-Hodgkin's Lymphoma (DLBCL) receiving allogeneic hematopoietic stem cell transplantation (allo-SCT) are valid, ASCT term mitigation and allo-SCT-sensitive best suited to take up the offer. Research search the European blood and marrow transplant group database of patient information between 1997-2006, incorporating ASCT DLBCL patients with recurrence and first allo-SCT. Other in a set of standards to accept allo-SCT &GE;18 years of age, and there is a human leukocyte antigen (HLA) sibling or unrelated combinations of the same type of Haploidentical donors. The results were included 101 patients (57 male, median age is 46 years old).　　Study on survival in patients with median follow-up time was 36 months. Results showed that 37 patients receiving myeloablative processing, 64 cases of patients accepted the reduced strength of pretreatment (RIC). 3 years non-recurrence and mortality (NRM) 28.2%[95% confidence intervals (CI) for 20%~39%], the relapse rate (RR) for 30.1% (95%CI 22%~41%), progress-free survival (PFS) rates for 41.7% (95%CI 32%~52%), overall survival (OS) rate was 53.8% (95%CI 44%~64%). Patients &GE;45 years of age (P=0.01) and after early ASCT (< 12 months) in patients with recurrent (P=0.01) NRM significantly increased. RR significantly elevated in patients with refractory (P=0.03). After the ASCT < recurrence and PFS reduce 12 month (P=0.03). RIC and lower PFS (P=0.1) and higher RR (P=0.1), but did not affect PFS and OS.　　Compatriots of the same study found no HLA and unrelated matched donors distribution above several study results are different. Related link: Allogeneic Stem-Cell Transplantation As Salvage Therapy for Patients With Diffuse Large B-Cell  Non-Hodgkin's Lymphoma Relapsing After an Autologous Stem-Cell Transplantation: An Analysis of the  European Group for Blood and Marrow Transplantation Registrywww.cmt.com.cn